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KMID : 1100620150020010044
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Clinical and Experimental Emergency Medicine
2015 Volume.2 No. 1 p.44 ~ p.50
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Clinical insights for early detection of acute transverse myelitis in the emergency department
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Huh Yo
Park Eun-Jung
Jung Ju-Won
Oh Sung-ho
Choi Sang-Cheon
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Abstract
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Objective:Acute transverse myelitis (ATM) is characterized by motor weakness, sensory changes, and autonomic dysfunction. However, diagnosis of ATM is based on early-stage clinical features only (and clarification of the cause of disease), which are difficult for emergency department (ED) physicians owing to low incidence rates. We performed retrospective analysis of ATM in order to provide clinical insights for early detection.
Methods:Medical records of patients, who were finally diagnosed with ATM from January 2005 to February 2013, were investigated. Data, including demographics, clinical findings, and radiographic findings, were reviewed.
Results:Forty-six patients were included in the present study, with a mean age of 43.4 years. Sensory changes were identified in 45 patients (97.8%), motor weakness in 33 patients (71.7%), and autonomic dysfunction in 35 patients (76.1%). Thirty patients (65.2%) showed high signal intensity in T2-weighted magnetic resonance imaging (MRI), with lesions most frequently found in the thoracic level of the spinal cord (56.7%). There were discrepancies between sensory changes and levels of MRI lesions. Thirty-five patients (76.1%) were diagnosed with idiopathic ATM. Initial diagnostic impressions in the ED were herniated intervertebral disc (38.7%), stroke (19.4%), Guillain-Barre syndrome (12.9%), cauda equina syndrome (9.7%), ATM (9.7%), and others (9.7%).
Conclusion:When a patient presents with motor weakness, sensory changes, or autonomic dysfunction, ATM should be initially considered as a differential diagnosis, unless the ED physician’s impression after initial evaluation is clear.
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KEYWORD
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Myelitis, transverse, Emergency service, hospital, Diagnosis
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